Differential regulation of synaptic vesicle proteins by antidepressant drugs
نویسندگان
چکیده
منابع مشابه
Differential regulation of synaptic vesicle protein genes by target and synaptic activity.
Differentiation of presynaptic nerve terminals involves changes in gene expression; these may be regulated by synaptic transmission and/or by contact with the target muscle. To gain insight into the control of presynaptic differentiation, we examined the regulation by target and synaptic activity of synaptic vesicle protein (SVP) genes in the chick ciliary ganglion (CG). In the CG, two SVP gene...
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What are they called? The uptake and storage of neurotransmitters is taken care of by the imaginatively named ‘neurotransmitter transporter proteins’ (as well as by ion channels and a proton ATPase). The synaptic vesicle proteins in the membrane trafficking class have mostly been given the prefix ‘synapto’, from the Latin meaning ‘to attach together’, and a suffix supposed to reflect a particul...
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The assembly of SNARE complexes between syntaxin, SNAP-25 and synaptobrevin is required to prime synaptic vesicles for fusion. Since Munc18 and tomosyn compete for syntaxin interactions, the interplay between these proteins is predicted to be important in regulating synaptic transmission. We explored this possibility, by examining genetic interactions between C. elegans unc-18(Munc18), unc-64(s...
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Serotonin, a neuromodulator at the crayfish neuromuscular junction, regulates neurotransmission without changing intracellular calcium levels. However, the mechanism of this regulation remains unclear. By analysis of synaptic depression using a depletion model and measurement of vesicle recycling using the styryl dye FM1-43, we show that serotonin increases the number of vesicles available for ...
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Complex brain functions, such as learning and memory, are believed to involve changes in the efficiency of communication between nerve cells. Therefore, the elucidation of the molecular mechanisms that regulate synaptic transmission, the process of intercellular communication, is an essential step toward understanding nervous system function. Several proteins associated with synaptic vesicles, ...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2004
ISSN: 1470-269X,1473-1150
DOI: 10.1038/sj.tpj.6500229